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The Causes of Type 2 Diabetes The exact cause of type 2 diabetes is unknown, although it is likely that many contributing factors result in type 2 diabetes. It can run in families, but the single genetic factor that causes it has not been found. Obese people are more likely to develop type two diabetes than skinny people. Scientists think that when people consistently overeat, the pancreas cannot produce enough insulin to control the large amount of gloucose that has been ingested. Below is a flow diagram that lists some suspected contributing factors of type two diabetes.